From basic research to clinics

Myelotracker has been characterized and validated in basic research projects, to detect and study human and animal myeloid cells’ recruitment to inflamed sites and allowed to reveal novel myeloid cell functions. Myelotracker may be used in biochemical studies, but also using imaging and flow cytometry techniques. Series of Myelotracker derivatives were synthesized and validated to allow their broad use either on fixed preparation, or with living cells or organisms.

In patients, localizing inflamed organs or determining the inflammatory status of tumors using represent a major challenge to improve diagnosis and treatment outcomes. Current developments aim at bringing Myelotracker to the clinic. In one hand, as a novel inflammation marker, by designing radiolabeled Myelotracker for the detection of inflamed tissues and organs using non-invasive imaging techniques (Pet-scan). In another hand, as a novel drug delivery molecule by conjugating Myelotracker with active drugs to improve their accumulation at inflamed sites, to further increase their effectiveness.

Detection of neutrophils from different mammal species with Myelotracker

Mouse neutrophils

Rabbit neutrophils

Human neutrophils

Fixed intestinal tissues labeled with Myelotracker-Dylight405 and Phalloidin-rhodamin (actin)